New Review on Cell–Cell Communication Published in Briefings in Bioinformatics!
We are excited to share our latest review article, “Advances and challenges in cell–cell communication inference: a comprehensive review of tools, resources, and future directions”, now published in Briefings in Bioinformatics:
📖 https://doi.org/10.1093/bib/bbaf280
This review offers a detailed overview of the current landscape of computational methods and databases used to infer cell–cell communication.
Key highlights include:
🔍 Analysis of 26 ligand-receptor resources, highlighting differences in coverage, species, signaling types, etc-
🔍 Classification of 58 bioinformatics tools for CCC inference, evaluated by input data requirements, computational strategies (intercellular, intracellular, differential communication), and output characteristics, as well as implementation choices
🔍 It also features a curated online catalog of CCC resouces and tools, designed to support researchers in identifying the most appropriate methods based on their data and analysis goals: https://sysbiobig.gitlab.io/ccc-catalog
This work is a collaboration between groups from the Departments of Information Engineering and Biology at the University of Padova, the Institute of Biomedical Technologies at the National Research Council (CNR), and the RWTH Aachen Medical Faculty’s Institute for Computational Genomics.